Tenofovir Disoproxil Fumarate

Release time:2017-10-25 16:00:00

 (S) - [[2- (6-amino-9H-purin-9-yl) -1-methylphenyl-fumarate Ethoxy] methyl] phosphonic acid bis (iso-oxooxycarbonyloxymethyl) ester, English name Tenofovir Disoproxil Fumarate

      CAS: 201341-05-1
       Molecular formula: C19H30N5O10P
       Molecular weight: 519.445
       Melting point: 286-289 ° C

       This product is white crystalline powder; at room temperature is relatively stable, hygroscopicity, 25 ℃ when the water solubility of 13.4mg / ml, optical rotation of -18 ° -22 °. It is a novel nucleotide reverse transcriptase inhibitor, can be effective against a variety of viruses, for the treatment of viral infectious diseases, retroviruses and hepatitis B virus has a strong inhibitory effect.
       Tenofovir is an acyclic nucleoside antiviral drug that has the effect of inhibiting HBV polyglucoside and HIV reverse transcriptase. The active ingredient of tenofovir is the direct competitive Binds to a natural deoxyribose substrate and inhibits viral polymerase, and terminates the chain by inserting DNA. Is the first nucleotide analogue to be approved by the US Food and Drug Administration (FDA) for HIV-1 infection.
       Tylenolide is a drug in AIDS cocktail therapy, and studies have shown that it can effectively improve the monkey's ability to prevent immunodeficiency virus (similar to human HIV).
       Tylenolide is hardly absorbed by the gastrointestinal tract and is therefore esterified and salt to become tannofloxacin fumarate. Tylenolide is water-soluble and can be rapidly absorbed and degraded into the active substance, tenorofovir, and then tenofovir is transformed into the active metabolite tannofloxacin. The peak value of tenonovudine blood was measured within 1 to 2 hours after dosing. Tylenolide and food service can increase bioavailability by about 40%. Tennofine bisphosphonates have an intracellular half-life of about 10 h and can be administered once a day. Since the drug is not metabolized by the CYP450 enzyme, the possibility of interaction with other drugs caused by the enzyme is small. The drug mainly by glomerular filtration and active tubule transport system excretion, about 70% to 80% of the prototype by the urine excreted. For the treatment of HIV, HBV infection. This product and other reverse transcriptase inhibitors for HIV-1 infection, hepatitis B treatment.

       Fumarate fumarate ester product quality in line with US USP standards, specifications are as follows:
1-1G101160401O0.pngTechnical advantages
       The company and the Shanghai Fudan University, Wuhan University of Science and Technology and Jing Chu College of Technology to establish long-term cooperation mechanism, make full use of the technical advantages of colleges and universities, production, learning, research integration of the road, joint research and development of new drugs and product improvement, Reserve generation, research and development of the road, so that products always walk in the forefront of market demand. In April 2016, the company and the Chinese Academy of Engineering, Fudan University Professor Chen Fener to establish "academician workstation", in the future, the academician team of experts will be the development of enterprises to provide the most favorable technical support. The company has now made 14 patented technology, and two patents have entered the trial stage of the invention.