Tenofovir

Release time:2017-11-02 16:00:00

Tenofovir: alias tebuconafil or PMPA, chemical name: (R) -9- (2-phosphate methoxypropyl) -adenine, English name: Tenofovir



CAS: 147127-20-6
Molecular formula: C9H14N5O4P
Molecular weight: 287.21
Melting point: 276-280 ° C

       This product is white to white crystalline powder, is containing a chiral center of the adenine derivatives.

       Tylenolide product quality in line with corporate standards, specifications are as follows:

Process technology
       I am in the new product research and development, and always adhere to the development of safe and environmentally friendly pharmaceutical intermediates and raw materials for the main direction of development, high technology content. The pharmaceutical intermediates and raw materials production technology is relatively mature, has reached the leading domestic level of similar products, in full compliance with similar domestic production technology requirements; and in line with industrial policy requirements, can better reduce pollution, energy conservation and improve industrial development The

Product advantages
       At present, there is a major problem in the domestic products of Tylenolide, which is the impurity and ash problem, and the products to be put into production are small and the ash is low. Most of the impurities of other products are <1%, ash <5% , Purity> 98%, while the company's products, a single impurity is basically <0.5%, ash <0.3%, purity> 99%. As the company has optimized the process to improve the reaction and crystallization conditions, making the product content is high, in the follow-up treatment, recrystallization and other aspects of a major improvement, effectively guarantee the quality of products, to avoid the previous color deepening, content Reduce the shortcomings of a number of domestic and foreign customers of the company's product quality has also been fully affirmed.

Technical advantages
        The company and the Shanghai Fudan University, Wuhan University of Science and Technology and Jing Chu College of Technology to establish long-term cooperation mechanism, make full use of the technical advantages of colleges and universities, production, learning, research integration of the road, joint research and development of new drugs and product improvement, Reserve generation, research and development of the road, so that products always walk in the forefront of market demand. In April 2016, the company and the Chinese Academy of Engineering, Fudan University Professor Chen Fener to establish "academician workstation", in the future, the academician team of experts will be the development of enterprises to provide the most favorable technical support. The company has now made 14 patented technology, and two patents have entered the trial stage of the invention.

Product Usage
       Tenofovir is an acyclic nucleoside antiviral drug that inhibits the role of HBV multimerase and HIV reverse transcriptase. Tenofovir bisphosphonates, the active ingredient of tenofovir, can be obtained by direct competition Binds to a natural deoxyribose substrate and inhibits viral polymerase, and terminates the chain by inserting DNA. Is the first nucleotide analogue to be approved by the US Food and Drug Administration (FDA) for HIV-1 infection.
Tylenolide is a drug in AIDS cocktail therapy, and studies have shown that it can effectively improve the monkey's ability to prevent immunodeficiency virus (similar to human HIV).
       Tenofovir is almost free from gastrointestinal absorption, so esterification, salt, become tenofovir dipivoxil fumarate. Tenofovir esters are water-soluble and can be rapidly absorbed and degrade into tenofovir, an active substance, and then tenofovir is transformed into the active metabolite tenofovir bisphosphate. 1 to 2 hours after administration of tenofovir plasma peak. Tenofovir and food service bioavailability can be increased by about 40%. The intracellular half-life of tenofovir bisphosphonates is about 10 h and can be administered once a day. Since the drug is not metabolized by the CYP450 enzyme, the possibility of interaction with other drugs caused by the enzyme is small. The drug mainly by glomerular filtration and active tubule transport system excretion, about 70% to 80% of the prototype by the urine excreted. For the treatment of HIV, HBV infection. This product and other reverse transcriptase inhibitors for HIV-1 infection, hepatitis B treatment.