Brand New Chemical Reaction First to Destroy the Strongest C

Release time:2017-11-02 13:41:56

       [Chinese chemical instrument network laboratory dynamic] guide: A new chemical reaction completely subverts the traditional reaction mode in which the weakest chemical bond are firstly destroyed. This new chemical reaction will decompose the strongest chemical key firstly and form new intermediates in the chemical synthesis. This subversion of the traditional chemical reaction model proves that chemists are able to creatively obtain some of the compounds which can not be met by conventional methods. Related papers are published in the "American Chemical Association Journal". 

       Researchers at Princeton University in the United States use catalysts for systems.By the synergistic effect of two catalysts, the strongest chemical bond(nitrogen-hydrogen bond (N-H)) in the molecule of the proton-coupled electron transfer reaction (PCET) is broken at first. Many important biological systems such as photosynthetic systems and respiratory systems are using PCET to destroy chemical strong bonds. Since there is no way to know which catalysts are available in PCET, this principle has not been applied in the synthesis of new molecules.

       According to the physicist organization network reported that the researchers selected a simple mathematical formula. This formula can help them to calculate exactly the strength of the strongest chemical bond disconnected when any pair of catalysts are working synergisticly, and they name it "effective bond strength value ".

       Researchers in the laboratory verified the efficiency of this formula. There is a serious correlation between the effective bond strength value and the reaction efficiency. When the effective bond strength value is higher or lower than the nitrogen-hydrogen bond strength value, the intermediate yield will be low. And when these two values are the same,  the intermediate yield will be very high.

       The major author of the paper, Gilbert Tsai successfully found this pair of magical catalysts system and studied the mechanism of the catalysts in-depth. He found that dibutyl phosphate one of the catalysts was the first to initiate a chemical reaction. It can rip out the hydrogen atoms from the  nitrogen - hydrogen bonds continuously, so that nitrogen - hydrogen bond is longer and longer, and gradually weakened. Another catalyst, the iridium compound, targets the weakened nitrogen-hydrogen bond, "pulls" electrons from the chemical bond, and cuts off the chemical bond from the middle.

       After the nitrogen-hydrogen bond is disconnected, the resulting nitrogen intermediates are very active and can be combined with carbon to form carbon-nitrogen bonds, leading to more complex chemical products

       The new study provides a platform for developing new chemical reactions without discovering the true features of PCET catalysts, and even can creates greater value.

       Robert Laurel, an associate professor of chemistry who led the study, said the idea would open a whole new chemical field.